Defined in the broadest sense, Glycobiology is the study of the structure, biosynthesis, biology, and evolution of saccharides (sugar chains or glycans) that are widely distributed in nature in all living life forms. Glycobiology is now one of the more rapidly growing fields in the natural sciences, with broad relevance to many areas of basic research, biomedicine, and biotechnology. The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, roles of glycans in complex biological systems, and their analysis or manipulation by various techniques. The third edition of this primary textbook in the field continues in the prior tradition, seeking to provide basic overview of Glycobiology, directed towards the advanced undergraduate or the beginning graduate-level student of molecular and cellular biology and biomedicine. While efforts have been made to avoid a major increase in overall length of the text, substantial changes and improvements include the following:



· Broader focus on all lineages of life forms in nature.


· Wider range of topics, ranging from biology and medicine to chemistry and materials science.


· Expanded international editorial board representing a wider range of expertise.


· Wider range of contributing authors with expertise in specific areas.


· Greatly expanded monosaccharide symbol nomenclature for the representation of glycans.


· Greater attention to informatics, and integration with databases on other classes of molecules.

Preliminary

Part I. General Principles
1. Historical Background and Overview
2. Monosaccharides and Their Linkages
3. Oligosaccharides and Polysaccharides
4. Cellular Organization of Glycosylation
5. Glycosylation Precursors
6. Glycosyltransferases and Glycan-processing Enzymes
7. Biological Functions of Glycans
8. A Genomic View of Glycobiology

Part II. Structure and Biosynthesis
9. N-Glycans
10. O-GalNAc Glycans
11. Glycosphingolipids
12. Glycosylphosphatidylinositol Anchors
13. Other Classes of Eukaryotic Glycans
14. Structures Common to Different Glycans
15. Sialic Acids and other Nonulosonic Acids
16. Hyaluronan
17. Proteoglycans and Sulfated Glycosaminoglycans
18. Nucleocytoplasmic Glycosylation
19. The O-GlcNAc Modification

Part III. Glycans in Evolution and Development
20. Evolution of Glycan Diversity
21. Eubacteria
22. Archaea
23. Fungi
24. Viridiplantae and Algae
25. Nematoda
26. Arthropoda
27. Deuterostomes

Part IV. Glycan-binding Proteins
28. Discovery and Classification of Glycan-Binding Proteins
29. Principles of Glycan Recognition
30. Structural Biology of Glycan Recognition
31. R-type Lectins
32. L-type Lectins
33. P-type Lectins
34. C-type Lectins
35. I-type Lectins
36. Galectins
37. Microbial Lectins: Hemagglutinins, Adhesins, and Toxins
38. Proteins that Bind Sulfated Glycosaminoglycans

Part V. Glycans in Physiology and Disease
39. Glycans in Glycoprotein Quality Control
40. Free Glycans as Signaling Molecules
41. Glycans in Systemic Physiology
42. Bacterial and Viral Infections
43. Parasitic Infections
44. Genetic Disorders of Glycan Degradation
45. Genetic Disorders of Glycosylation
46. Glycans in Acquired Human Diseases
47. Glycosylation Changes in Cancer

Part VI. Methods and Applications
48. Antibodies and Lectins in Glycan Analysis
49. Glycosylation Mutants of Cultured Cells
50. Structural Analysis of Glycans
51. Glycomics and Glycoproteomics
52. Glycobioinformatics
53. Chemical Synthesis of Glycans and Glycoconjugates
54. Enzymatic Synthesis of Glycans and Glycoconjugates
55. Chemical Tools for Inhibiting Glycosylation
56. Glycosylation Engineering
57. Glycans in Biotechnology and Pharmaceutical Industry
58. Glycans in Nanotechnology
59. Glycans in Bioenergy and Material Science
VII. Future Directions
60. Future Directions in the Glycosciences

Index