Charney and Nestler's Neurobiology of Mental Illness

The Sixth Edition of Charney and Nestler's Neurobiology of Mental Illness builds on previous editions of the book and reflects the continuing progress in reintegrating psychiatry into the mainstream of modern biomedical science. This reintegration remains a work in progress, based on the unique complexity of the brain and its diseases. Yet, the research tools that are transforming other branches of medicine-epidemiology, genetics, epigenetics, molecular and cell biology, imaging, and medicinal chemistry, along with fundamental advances in the neurosciences that make it possible to decipher cell types and their larger circuits to an unprecedented degree, are now at long last transforming psychiatry.

Collectively, the 75 chapters in this newly renovated textbook describe the developments in genetics and in molecular, cellular, and systems neuroscience that are breaking new ground in the diagnosis, treatment, and prevention of disabling psychiatric disorders.

In this updated edition, Section 1 focuses on the major methodological approaches to studying the biological basis of mental illness. Sections 2 through 8 each focus on a major class of mental illness, including schizophrenia, bipolar disorder, depression, anxiety and trauma disorders, substance use disorders, neurodegenerative disorders, and childhood psychiatry disorders.

The final section is a collection of essays that address what can be expected over the next decade in terms of improving psychiatric diagnosis, achieving a true precision approach to treating mental illness, along with new avenues of medication and non-medication therapies in the offing.

Dennis S. Charney, MD
Anne and Joel Ehrenkranz,
Dean, Icahn School of Medicine at Mount Sinai
President for Academic Affairs
Mount Sinai Health System
Professor, Departments of Psychiatry, Neuroscience, and
Pharmacological Sciences
New York, NY
USA

Eric J. Nestler, MD, PhD
Nash Family Professor of Neuroscience
Director, Friedman Brain Institute
Dean for Academic Affairs
Icahn School of Medicine at Mount Sinai
Chief Scientific Officer of the Mount Sinai Health System
New York, NY
USA

Joseph D. Buxbaum, PhD
G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences
Deputy Chair, Department of Psychiatry
Director, Seaver Autism Center for Research and Treatment
Icahn School of Medicine at Mount Sinai
New York, NY
USA

Elisabeth B. Binder. MD
Director, Department of Genes and Environment
Max Planck Institute of Psychiatry
Munich, Germany

Joshua A. Gordon, MD
Director, National Institute of Mental Health
Bethesda, MD
USA

Marina R. Picciotto
Charles B. G. Murphy Professor of Psychiatry and Professor
Child Study Center, of Neuroscience and of Pharmacology
Director, Division of Molecular Psychiatry
Deputy Chair for Basic Science Research, Dept. of Psychiatry
Deputy Director, Kavli Institute for Neuroscience
Co-Director, Neuroscience Research Training Program
Yale Department of Psychiatry
New Haven, CT
USA