Brain Injury and Pediatric Cardiac Surgery
by Jonas; RichardFormat: Hardcover
Pub. Date: 1995-12-15
Publisher(s): CRC Press
List Price: $335.00
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Summary
An estimated 30,000 children are born in the USA with congenital heart disease each year, two thirds of which will require corrective surgery. Medical advances have formed a trend of operating on newborns rather than waiting until the child is older. Ten years ago, the mortality for these operationswas 60% to 70%. That percentage has dropped to 2%. This specialized book explores the basic mechanisms of neurologic injury associated with congenital heart surgery while covering the emerging technologies for assessment of neurologic integrity and injury. The text also highlights the current and future techniques for reducing and preventing these injuries, and reviews the pertinent medicolegal issues.
Table of Contents
| Contributing Authors | |
| Foreword | |
| Preface | |
| Brain Injury and Infant Cardiac Surgery: Overview | p. 1 |
| Brain Development and Its Relationship to Patterns of Injury | p. 13 |
| Maturation of Brain ATP Metabolism | p. 29 |
| EEG Maturation with Special Reference to Epileptogenic Effects of Hypoxia | p. 59 |
| Programmed Cell Death: The Biology of Cell Death in the Nematode Caenorhabditis elegans and Implications for the Understanding and Treatment of Human Brain Injury after Cardiac Surgery | p. 75 |
| The Neurological Examination | p. 87 |
| Cognitive and Psychomotor Developmental Assessment | p. 101 |
| EEG Methods with Particular Reference to Neonatal Seizures | p. 109 |
| Transcranial Doppler Technology: The Noninvasive Monitoring of Cerebral Perfusion During Cardiopulmonary Bypass | p. 129 |
| PET and SPECT in the Assessment of Cerebral Function | p. 143 |
| Brain Monitoring Using Optical Imaging and Optical Spectroscopy | p. 153 |
| Assessment of CNS Function: Cerebral Blood Flow and Metabolism | p. 185 |
| Cerebral Evaluation with Nuclear Magnetic Resonance Spectroscopy | p. 192 |
| Mechanisms of Perinatal Ischemic Brain Damage | p. 201 |
| Endothelial and White Cell Activation in Bypass and Reperfusion Injury: Brain Injury | p. 215 |
| Excitotoxicity and Nitric Oxide | p. 229 |
| A Newborn Canine Model of Hypothermic Circulatory Arrest | p. 241 |
| Effects of CPB, Hypothermia, and Circulatory Arrest on Cerebral Blood Flow and Metabolism | p. 255 |
| Assessment by NMRS of the Effects of Cardiopulmonary Bypass, Hypothermia, and Circulatory Arrest | p. 265 |
| pH Management During Hypothermic Cardiopulmonary Bypass with Circulatory Arrest | p. 271 |
| Methods and Procedures | p. 289 |
| EEG Findings | p. 311 |
| Neurologic and MRI Findings | p. 329 |
| Developmental Findings at One Year | p. 341 |
| Choreoathetosis | p. 353 |
| New Strategies for Brain Protection Including NMDA Receptor Antagonists | p. 365 |
| Cerebroplegia and Low Flow | p. 375 |
| Pharmacological Modification of a Cerebroplegia Solution | p. 385 |
| Index | p. 407 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
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