Biosensing Using Nanomaterials
by A. Merkoci (Institut Catala de Nanotecnologia in Barcelona, Spain )Format: eBook
Pub. Date: 2009-03-01
Publisher(s): Wiley-Interscience
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Summary
This book introduces novel concepts in the area of bioanalysis based on nanomaterials, opening new opportunities for basic research and new tools for real bioanalytical applications. Each chapter provides a theoretical overview of a different topic and includes an annex that describes the most interesting aspect related to the bioanalytical system. Biosensing Using Nanomaterials is an important resource for a broad audience involved in the research, teaching, learning, and practice of nanomaterials integration into biosensing systems for clinical, environmental, and industrial applications.
Table of Contents
| Contributors | |
| Series Preface | |
| Preface | |
| Carbon Nanotubes | |
| Carbon Nanotube-Based Sensors and Biosensors | |
| Introduction to the Structure of Carbon Nanotubes | |
| Electroanalysis Using CNT-Modified Electrodes | |
| Advantageous Application of CNTs in Sensors: pH Sensing | |
| Carbon Nanotube-Based Biosensors | |
| Using CNTs in Biosensor Production for Medical Diagnostics and Environmental Applications | |
| References | |
| Isotropic Display of Biomolecules on CNT-Arrayed Nanostructures | |
| Introduction: CNT Arrays for Biosensing | |
| Functionalization of CNTs: Controlling Display Through Covalent Attachment | |
| Self-Assembling Interfaces: Anchor-Probe Approach | |
| Molecular Wiring of Redox Enzymes | |
| Multiplexing Biomolecules on Nanoscale CNT Arrays | |
| Conclusions | |
| References | |
| Interaction of DNA with CNTs: Properties and Prospects for Electronic Sequencing | |
| Introduction | |
| Structural Properties of Combined DNA-CNT Systems | |
| Electronic Structure | |
| Optical Properties | |
| Biosensing and Sequencing of DNA Using CNTs | |
| Summary | |
| References | |
| Nanoparticles | |
| Improved Electrochemistry of Biomolecules Using Nanomaterials | |
| Introduction | |
| CNT-Based Electrochemical Biosensors | |
| Nanoparticle-Based Electrochemical Biosensors | |
| Quantum Dot-Based Electrochemical Biosensors | |
| Conclusions and Outlook | |
| References | |
| The Metal Nanoparticle Plasmon Band as a Powerful Tool for Chemo- and Biosensing | |
| Introduction | |
| The SPB: An Optical Property of Metal NPs | |
| Plasmon Band Variation Upon Aggregation of Nanoparticles | |
| Plasmon Band Variation on the Environment or Ligand Alteration | |
| Metal Nanoparticles as Labels | |
| Conclusions | |
| References | |
| Gold Nanoparticles: A Versatile Label for Affinity Electrochemical Biosensors | |
| Introduction | |
| Synthesis of AuNPs | |
| Characterization of AuNPs | |
| AuNPs as Detecting Labels for Affinity Biosensors | |
| Conclusions | |
| References | |
| Quantum Dots for the Development of Optical Biosensors Based on Fluorescence | |
| Introduction | |
| Quantum Dots | |
| Basic Photophysics and Quantum Confinement | |
| Quantum Dot Surface Chemistry and Bioconjugation | |
| Bioanalytical Applications of Quantum Dots as Fluorescent Labels | |
| Fluorescence Resonance Energy Transfer and Quantum Dot Biosensing | |
| Summary | |
| References | |
| Nanoparticle-Based Delivery and Biosensing Systems: An Example | |
| Introduction | |
| Functional Colloidal Nanoparticles | |
| Polyelectrolyte Capsules as a Functional Carrier System | |
| Uptake of Capsules by Cells | |
| Delivery and Sensing with Polyelectrolyte Capsules | |
| Conclusions | |
| References | |
| Luminescent Quantum Dot FRET-Based Probes in Cellular and Biological Assays | |
| Introduction | |
| Luminescent Quantum Dots | |
| Fluorescence Resonance Energy Transfer | |
| Quantum Dot FRET-Based Protease Probes | |
| Summary and Conclusions | |
| References | |
| Quantum Dot-Polymer Bead Composites for Biological Sensing Applications | |
| Introduction | |
| Quantum Dot-Composite Construction | |
| Applications of QD Composites | |
| Future Directions | |
| References | |
| Quantum Dot Applications in Biomolecule Assays | |
| Introduction to QDs and Their Applications | |
| Preparation of QDs for Conjugation with Biomolecules and Cells | |
| Special Optoelectronic Properties in the Bioemployment of QDs | |
| Employment of QDs as Biosensing Indicators | |
| References | |
| Nanoparticles and Inductively Coupled Plasma Mass Spectroscopy-Based Biosensing | |
| ICP-MS and Application Possibilities | |
| Detection of Metal Ions | |
| Detection of Nanoparticles | |
| Analysis of Metal-Containing Biomolecules | |
| Bioanalysis Based on Labeling with Metal Nanoparticles | |
| Conclusions | |
| References | |
| Nanostructured Surfaces | |
| Integration Between Template-Based Nanostructured Surfaces and Biosensors | |
| Introduction | |
| Nanosphere Lithography | |
| Nanoelectrodes Ensemble for Biosensing Devices | |
| Concluding Remarks | |
| References | |
| Nanostructured Affinity Surfaces for MALDI-TOF-MS-Based Protein Profiling and Biomarker Discovery | |
| Proteomics and Biomarkers | |
| Maldi in Theory and Practice | |
| Carbon Nanomaterials | |
| Near-Infrared Diffuse Reflection Spectroscopy of Carbon Nanomaterials | |
| References | |
| Nanopores | |
| Biosensing with Nanopores | |
| Nanoporous Materials in Sensing | |
| Nanochannel and Nanopore Fabrication | |
| Surface Modification Chemistry | |
| Nonelectrical Nanoporous Biosensors | |
| Electrical Nanoporous Biosensors | |
| Summary | |
| References | |
| Index | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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