Antiepileptic Drugs: Combination Therapy and Interactions,9780521822190

Antiepileptic Drugs: Combination Therapy and Interactions

by
ISBN13: 9780521822190
ISBN10: 052182219X
Format: Hardcover
Pub. Date: 2005-07-11
Publisher(s): Cambridge University Press
List Price: $219.00

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Summary

This book reviews the use of antiepileptic drugs focusing on the interactions between these drugs and between antiepileptics and other drugs. These interactions can be beneficial or can cause harm. The aim of this book is to increase awareness of the possible impact of combination pharmacotherapies. Pharmacokinetic and pharmacodynamic interactions are discussed supported by clinical and experimental data. The book consists of five sections covering the general concepts and advantages of combination therapies, the principles of drug interactions, the mechanisms of interactions, drug interactions in specific populations or in patients with co-morbid health conditions, and concludes with a look at the future directions for this field of research. The book will be of interest to all who prescribe antiepileptics to epileptic and non-epileptic patients, including epileptologists, neurologists, neuro-pediatricians, psychiatrists and general practitioners.

Table of Contents

List of contributors ix
Foreword
Giuliano Avanzini
xiii
Foreword
Torbjörn Tomson
xv
Acknowledgements xvii
Part I Introduction 1(44)
1 Combination therapy of diseases: general concepts
3(13)
Emma Mason and Philip A. Routledge
2 Combination therapy with antiepileptic drugs: potential advantages and problems
16(10)
Richard H. Mattson
3 Pharmacogenetic aspects
26(21)
Matthew C. Walker, Michael R. Johnson and Philip N. Patsalos
Part II Pharmacokinetic interactions 45(134)
4 Pharmacokinetic principles and mechanisms of drug interactions
47(10)
Philip N. Patsalos
5 Predictability of metabolic antiepileptic drug interactions
57(36)
Edoardo Spina, Emilio Perucca and Rene Levy
6 Influence of food and drugs on the bioavailability of antiepileptic drugs
93(18)
Carlos A. Fontes Ribeiro
7 Interactions between antiepileptic drugs
111(28)
Bernhard Rambeck and Theodor W. May
8 Interactions between antiepileptic and non-antiepileptic drugs
139(42)
Jerzy Majkowski and Philip N. Patsalos
Part III Pharmacodynamic interactions 179(76)
9 Pharmacodynamic principles and mechanisms of drug interactions
181(12)
Blaise F.D. Bourgeois
10 Methods for assessing pharmacodynamic interactions
193(15)
Blaise F.D. Bourgeois
11 Experimental studies of pharmacodynamic interactions
208(20)
Stanislaw J. Czuczwar
12 Clinical studies of pharmacodynamic interactions
228(13)
John R. Pollard and Jacqueline French
13 Clinical studies of pharmacodynamic interactions between antiepileptic drugs and other drugs
241(14)
Gaetano Zaccara, Andrea Messori and Massimo Cincotta
Part IV Drug interactions in specific patient populations and special conditions 255(164)
14 Antiepileptic drug interactions in children
257(16)
Olivier Dulac, Elizabeth Rey and Catherine Chiron
15 Antiepileptic drug interactions in the elderly
273(21)
Jeannine M. Conway and James C. Cloyd
16 Antiepileptic drug interactions in pregnancy
294(31)
Mark S. Yerby
17 Antiepileptic drug interactions in handicapped and mentally retarded patients
325(16)
Matti Sillanpää
18 Antiepileptic drugs and sex steroids
341(9)
Richard H. Mattson
19 Antiepileptic drug interactions in patients requiring psychiatric drug treatment
350(19)
Michael R. Trimble and Marco Mula
20 Antiepileptic drugs in non-epileptic health conditions: possible interactions
369(23)
Jerzy Majkowski
21 Drug monitoring in combination therapy
392(11)
Walter Fröscher
22 Cognitive side-effects due to antiepileptic drug combinations and interactions
403(16)
Albert P. Aldenkamp, Mark de Krom, Irene Kotsopoulos and Jan Vermeulen
Part V Conclusions and future perspectives 419(56)
23 Selection of drug combinations in clinical practice: current and future perspectives
421(20)
Jerzy Majkowski
24 Future research: an experimental perspective
441(17)
Rob A. Voskuyl, Daniel M. Jonker and Fernando H. Lopes da Silva
25 Future research: a clinical prospective
458(17)
Carlos A. Fontes Ribeiro
Index 475

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